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Image Search Results
Journal: Frontiers in immunology
Article Title: Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.
doi: 10.3389/fimmu.2023.980247
Figure Lengend Snippet: FIGURE 1 Global analysis and distribution of miRNA-seq in RA and SSc monocytes. Heatmap of significantly dysregulated miRNA in RA (A) and SSc (B) monocytes compared to HC. Principal component analysis (PCA) plot of global miRNA distribution in RA (green), SSc (blue) and HC (red) monocytes (C). Enrichment analysis of abundantly expressed miRNA regulating selected genes involved in immune pathways in RA (D) and SSc monocytes (E). Heatmap analysis of selected miRNA in RA (F) and SSc (G) monocytes compared to HC.
Article Snippet: Circulating miRNA validation in RA and SSc sera and RA synovial fluids The volume of 300 μl of sera or plasma from SSc (n=10), RA (n=44) patients and and HC (n=37) patients was used to isolate circulating miRNA using
Techniques:
Journal: Frontiers in immunology
Article Title: Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.
doi: 10.3389/fimmu.2023.980247
Figure Lengend Snippet: FIGURE 2 The level of circulating miRNA in RA and SSc patients. The level of miRNA-19b-3p (A), miRNA-29c-5p (B), miRNA-374a-5p (C), miRNA-503-5p (D), miRNA-589-5p (E), miRNA-3614-5p (F) in sera of RA and SSc patients compared to HC. P-values were expressed as follows: ns for not significant; 0.05 > P > 0.01 as *; 0.01 > P > 0.001 as **; P < 0.001 as ***, P <0.0001 as ****.
Article Snippet: Circulating miRNA validation in RA and SSc sera and RA synovial fluids The volume of 300 μl of sera or plasma from SSc (n=10), RA (n=44) patients and and HC (n=37) patients was used to isolate circulating miRNA using
Techniques:
Journal: Frontiers in immunology
Article Title: Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.
doi: 10.3389/fimmu.2023.980247
Figure Lengend Snippet: FIGURE 3 The levels of circulating miRNA in body fluids of eRA and aRA patients. The levels of miRNA-19b-3p (A), miRNA-29c-5p (B), miRNA-374a-5p (C), miRNA-503-5p (D), miRNA-589-5p (E), miRNA-3614-5p (F) in sera or eRA and aRA and SF of aRA patients compared to HC. P-values were expressed as follows: ns for not significant; 0.05 > P > 0.01 as *; 0.01 > P > 0.001 as **; P < 0.001 as ***, P <0.0001 as ****.
Article Snippet: Circulating miRNA validation in RA and SSc sera and RA synovial fluids The volume of 300 μl of sera or plasma from SSc (n=10), RA (n=44) patients and and HC (n=37) patients was used to isolate circulating miRNA using
Techniques:
Journal: Frontiers in immunology
Article Title: Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.
doi: 10.3389/fimmu.2023.980247
Figure Lengend Snippet: FIGURE 4 KEGG pathway analysis of selected 6 miRNA candidates and their potential target genes. The identification of specific pathways (A) and their downstream genes (B) including HLA-DOA and HLA-DQA1, which were predicted to be negatively regulated by significantly changed miRNA in RA patients, using the Diana-miPath tool. The fold change analysis of expression level of HLA class II genes between HC and RA monocytes from RNA- seq (B) based of FDR < 0.01 and p-values < 0.05.
Article Snippet: Circulating miRNA validation in RA and SSc sera and RA synovial fluids The volume of 300 μl of sera or plasma from SSc (n=10), RA (n=44) patients and and HC (n=37) patients was used to isolate circulating miRNA using
Techniques: Expressing, RNA Sequencing
Journal: Frontiers in immunology
Article Title: Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of monocytes.
doi: 10.3389/fimmu.2023.980247
Figure Lengend Snippet: FIGURE 5 The levels of circulating miRNA in HC and RA patients upon baricitinib therapy. The levels of miRNA-19b-3p (A), miRNA-29c-5p (B), miRNA-374a-5p (C), miRNA-503-5p (D), miRNA-589-5p (E), miRNA-3614-5p (F) before and 3 months after baricitinib treatment in RA patients compared to HC. ROC analysis of changes/delta in miRNA-19b-3p and miRNA-503-5p expression and CRP level upon JAKi therapy (G). Correlation analysis between the expression of delta miRNA-19b-3p and delta DAS28 in baricitinib-treated RA patients (H). P-values were expressed as follows: ns for not significant; 0.05 > P > 0.01 as *; 0.01 > P > 0.001 as **; P < 0.001 as ***, P <0.0001 as ****.
Article Snippet: Circulating miRNA validation in RA and SSc sera and RA synovial fluids The volume of 300 μl of sera or plasma from SSc (n=10), RA (n=44) patients and and HC (n=37) patients was used to isolate circulating miRNA using
Techniques: Expressing